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10.2.1 DynaCache not enabled
The first issue we identified was that DynaCache had not been enabled.
Although this seems obvious in hindsight, it was not considered by the application development team because they were focused on function, not performance. Since this was the first WebSphere application to be deployed for the company that had response time issues, the integration team had no prior knowledge of DynaCache.
Just enabling DynaCache in it's "out of the box" configuration did not yield any significant gains in page performance. The cachespec.xml needed customization.